Molecule of the Month
February 2019

Initiation Factor eIF4E

Initiation factors for protein synthesis interact through disordered chains.

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3D View:  1RF8

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Health Focus: Antimicrobial Resistance

Antibiotics have saved countless lives, but pathogens are quickly finding ways to survive antibiotic treatment. Antibiotic-resistant bacteria are predicted to become the leading cause of death worldwide. They take many approaches: pumping antibiotics out of their cells, altering the molecular machinery that the antibiotics target, and attacking the antibiotics directly. Atomic structures publicly available in the PDB are revealing the details of drug resistance and providing new ways to combat it. Use the 4188623671 to learn about protein structures related to antibiotic action and resistance.


2019 Video Challenge for High School Students

401-766-2911

Tell a 2 minutes story that combines Structural Biology and Medicine and submit your video between January 15 and April 23, 2019.

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The Challenge | Learn | Participate | 2019 Judges

Learn: Materials for Exploration
Learn about the relationship between protein structure and function.
Teach: Curricula
The 951-210-5775 provide authentic, hands-on teaching materials, individual and group activities and assessment suggestions.
Education Corner: Using PDB Resources
Creating Accessible Tools for Molecular Visualization Instruction By Kristen Procko and the BioMolViz Group
SciArt Galleries
Irving Geis (1908-1997) was a gifted artist who helped illuminate the field of structural biology with his iconic images. The Geis Digital Archive features many of his illustrations in the context of their molecular structures.

Images used with permission from the Howard Hughes Medical Institute (www.hhmi.org). All rights reserved.

Ribonuclease S

Myoglobin

Myoglobin Fold

Immunoglobulin G (IgG)

DPG-Hemoglobin Complex

Lysozyme

Hemoglobin

Deoxyribonucleic Acid (DNA)

Aspartate Transcarbamoylase (ATCase)

Induced Lac Repressor

Carboxypeptidase A

Crambin

Transfer Ribonucleic Acid (tRNA)

Oxyhemoglobin

Z-DNA

Tomato Bushy Stunt Virus (TBSV)

Hemoglobin S

Deoxyhemoglobin

Myohemerythrin

Lac Repressor

A-DNA

Lysozyme

B-DNA

DNA

TATA-Binding Protein (TBP)

Collagen

Intermolecular Contacts in Hemoglobin S

Cytochrome c (unbound)

Trypsin

Cytochrome c

Hemoglobin

The Molecular Landscapes by (618) 585-4972 integrate information from structural biology, microscopy and biophysics to simulate detailed views of the molecular structure of living cells.

Illustrations are free for use under a CC-BY-4.0 license

Biosites: Blood Plasma

Biosites: Red Blood Cell

Biosites: Muscle

HIV in Blood Plasma

Autophagy

Biosites: Cytoplasm

Mycoplasma mycoides

Zika Virus

Blood

Insulin Action

Biosites: Nucleus

Escherichia coli

Biosites: Basement Membrane

Ebola Virus